alexa Haigang Gu | Vanderbilt University School of Medicine
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Haigang Gu

Haigang Gu Haigang Gu
Postdoctoral Fellow
Vanderbilt University School of Medicine
Nashville, USA
Read Interview session with Haigang Gu
Biography

Haigang Gu, cuurently Postdoctoral researcher in Vanderbilt University School of Medicine, Nashville, USA. Haigang Gu has received his PhD in also in Emory University during the period of 2010-2011.

Research Interest

My current research is to understand how transcriptional factors affect neuronal differentiation and maturation and synaptic transmission and recycling in vitro and in vivo using stem cell-derived neurons, primary cultured neurons and brain slices by whole cell patch clamp recording and super-resolution live cell imaging. The underlying mechanisms could be extended to illustrate the functional recovery of neurological disease treated by drugs and stem cells. Recently, I have cloned most of neuronal transcriptional factors (15 genes) in lentiviral-based vector and packaged these vectors in lentivirus. We have developed some new protocols to induce stem cells, embryonic stem cells and neural stem cells to differentiate into neurons using defined chemicals and transcriptional factors related to neuronal differentiation and maintenance. Furthermore, we have made substantial progress on the synaptic transmission and recycling trafficking in cultured hippocampus, cortical and midbrain neurons. My research has been mainly focus on understanding (1) the mechanisms of proliferation and neuronal differentiation of embryonic stem cells and adult stem cells, such as neural stem cells and mesenchymal stem cells, (2) stem cell-based therapies for the treatment of such as Alzheimer’s disease and ischemic stroke, and (3) sustained release neurotrophic factors or neurotrophic factor genes for the treatment of neurodegenerative disease. I have strong background and extensive experience in molecular and cellular biology, stem cell culture and differentiation, whole cell patch clamp recording in cultured cells, live cell imaging as well as animal models, such as Parkinson’s, Alzheimer’s disease and ischemic stroke.

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Publications

Stem Cell-Derived Dopamine Neurons for the Treatment of Neurodegenerative Diseases
Haigang Gu
Review Article: Clin Pharmacol Biopharm 2013, 2:111
DOI: 10.4172/2167-065X.1000111
 
Modeling and Therapeutic Strategies of Pluripotent Stem Cells for Alzheimer ’ s Disease
Haigang Gu
Editorial: J Stem Cell Res Ther 2013, 3:e115
DOI: 10.4172/2157-7633.1000e115
 
Using Induced Pluripotent Stem Cells to Model Neurodegenerative Diseases
Haigang Gu
Editorial: J Anc Dis Prev Rem 2013,1: e101
DOI: 10.4172/2329-8731.1000e101
 
Application of Nerve Growth Factor in Alzheimer's Disease
Haigang Gu and Dahong Long
Editorial: Clin Pharmacol Biopharm 2012, 1:e109
DOI: 10.4172/2167-065X.1000e109
 
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