alexa Editor - Jie Luo | Institute for Systems Biology | 7553
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
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Jie Luo

Jie Luo Jie Luo
Research Scientist
Institute for Systems Biology
Seattle WA
USA
Read Interview session with Jie Luo
Biography

My research is mainly focused on understanding of the mechanism of activated transcription using quantitative mass spectrometry and mapping the protein-protein interactions in large protein complexes using chemical crosslinking and mass spectrometry. I have designed and synthesized new crosslinkers along with new programs and searching tools to facilitate the enrichment and characterization of crosslinked peptides using mass spectrometry and successfully applied these techniques in studying of protein architecture of pol II complex from partially immuno-purified samples.  I have involved in designing a new target quantitative mass spectrometry platform (iMSTIQ), which can trigger MS2 quantification independent of the ion intensity using LTQ-Orbitrap. I have also worked on the study of the mechanism of gene activation in yeast and identified a new gene GDS1 involving in the attenuation of SAGA and NuA4 transcription activation. I worked on a novel polymerase, pol IV, involving in siRNA mediated gene silence in plant for my PhD theses.

Research Interest

My research is mainly focused on understanding of the mechanism of activated transcription using quantitative mass spectrometry and mapping the protein-protein interactions in large protein complexes using chemical crosslinking and mass spectrometry.

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Publications

Crosslinkomics---A New Era of Mapping Protein-Protein Interactions
Jie Luo and Jeff Ranish
Editorial: JPB / Vol.4.12 viii-viii (2011)
DOI: 10.4172/jpb.100000e8
 

Journal of Proteomics & Bioinformatics - Mapping protein-protein interactions and architecture of large protein complexes using mass spectrometry


Mapping protein-protein interactions and architecture of large protein complexes using mass spectrometry

Presented by: Jie Luo
Institute for Systems Biology
USA 

My research is mainly focused on understanding of the mechanism of activated transcription using quantitative mass spectrometry and mapping the protein-protein interactions in large protein complexes using chemical crosslinking and mass spectrometry. I have designed and synthesized new crosslinkers along with new programs and searching tools to facilitate the enrichment and characterization of crosslinked peptides using mass spectrometry and successfully applied these techniques in studying of protein architecture of pol II complex from partially immuno-purified samples.  I have involved in designing a new target quantitative mass spectrometry platform (iMSTIQ), which can trigger MS2 quantification independent of the ion intensity using LTQ-Orbitrap. I have also worked on the study of the mechanism of gene activation in yeast and identified a new gene GDS1 involving in the attenuation of SAGA and NuA4 transcription activation. I worked on a novel polymerase, pol IV, involving in siRNA mediated gene silence in plant for my PhD theses.

 
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