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I obtained my B.S, Chemistry, Madurai Kamaraj University, India. Has done M.S, Applied Chemistry and Phd Bio-Inorganic Chemistry, National Institute of Technology, Bharathidasan University, India. Was Post-Doctoral Research Associate in Massachusetts General Hospital / Harvard Medical School, Boston. Currently Assistant Professor, Department of Radiation Oncology The Ohio State University College of Medicine / Comprehensive Cancer Center.
My research focus is to bridge the gap between basic and clinical research. To this end, we explore transcriptomic, epigenetic, metabolomic, proteomic and genomic profiles in patient tumor biopsy samples to identify predictive and prognostic markers and validate therapeutic targets using pre-clinical models. We are also working to identify the underlying mechanisms of chemo and radiation resistance in treatment-refractory tumors by short-circuiting signal transduction pathways and determining the mutational status, gene and molecular signatures mediating treatment resistance. We have developed cancer stem cell models to investigate cancer stem cell biology via protein-protein interactions at translational and transcriptional levels. We are conducting correlative biology studies in patient cohorts to determine whether a particular gene, protein, or metabolite contributes to progression free survival, overall survival, and toxicity.
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