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Anatomy & Physiology: Current Research
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Manus Jonathan Paul Biggs

Manus Jonathan Paul Biggs Manus Jonathan Paul Biggs
Department of Applied Physics and
Applied Mathematics
Columbia University
New York

Dr. Biggs graduated from the National University of Ireland, Galway in 2003 with a B.Sc in anatomy, and an M.Sc in biomedical science, completing a research into the fabrication of bioscaffolds for soft-tissue regeneration. Dr. Biggs was awarded a Ph.D in January 2008 from the University of Glasgow,withfunding secured from the AO Research Institute, Switzerland. His research was concerned with the effects of nanoscale topography on osteoblast adhesion and progenitor cell function. While preparing to submit his thesis for the degree of Ph.D, Dr.Biggs was awarded postdoctoral funding for six months to further investigate mechanotransduction in endothelial cells.In 2009 Dr. Biggs was invited to commence postdoctoral research at Columbia University, where he is currently engaged in the development of novel adoptive immunetherapies through the use of small technologies, with a goal to modulating differential function in human T-cell populations.

Research Interest

Nanofabrication and small technologies
Cellular adhesion
Biomaterials Osteospecific differentiation through mechanotransduction Osteospecific signalling pathways
T-cell differentiation through mechanotransduction
Dynamics of the immunological synapse


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