alexa Editor - Marek Malecki | Western University of Health Sciences | 9993
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
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Marek Malecki

Marek Malecki Marek Malecki
Associate Professor of Genetics, Genomics, and Gene Therapy
Western University of Health Sciences

He earned MD degree at the Medical Academy, Poznan followed by Residency/Fellowship in Molecular Medicine in Rigshospitalet, Copenhagen. He earned PhD at the Polish Academy of Sciences, Warsaw followed by the postdoctoral fellowships in molecular biology at the Austrian Academy of Sciences, Salzburg, ETH, Zurich, Utrecht University, Utrecht, Cancer Center, Vienna, Cancer Center, Amsterdam, Biozentrum, Basel. He is currently Associate Professor of Genetics, Genomics, and Gene Therapy at the Western University, Pomona, CA and President of Phoenix Biomolecular Engineering Foundation, San Francisco, CA.

Marek Malecki MD PhD developed a cancer suicide gene therapy. It was initially developed for ovarian cancers as the means of targeted elimination of cancer cells, while retaining healthy cells intact. This is the best way to retain women’s fertility in cases of cancer. It is based upon the synthetic scFv and probes, which he invented and patented (USPTO and WIPO). A big role in this gene therapy is played by the nuclear routing network, which he discovered during his tenure at the NIH, National Biotechnology Resource. He also developed the unique protocols of cryo-immobilization of living cells which retain their high viability.

Research Interest

Cancer of ovaries, cancer of testes, cancer stem cells (CSC), circulating tumor cells (CTCs), genetic disorders, iatrogenic genetic mutations, gene therapy, targeted gene delivery, site specific recombination, fertility sparing therapy, biobanking, in vitro fertilization.


Global Speakers in the subject

Global Experts in the subject


Novel Approach for Designing Supportive Care in Genetic Disorders of Gastrointestinal Tract: Three-Dimensional Polymer Model of Nutritional Therapies in Cystic Fibrosis, Ulcerative Colitis, and Crohn`s Disease
Paul Zarogoulidis , Ioannis Kioumis , Theodora Tsiouda , Nikolaos Pezirkianidis , Christos Ritzoulis , Haidong Huang , Wolfgang Hohenforst-Schmidt , Dionysios Spyratos , Konstantinos Porpodis , Georgia Pitsiou , Sofia Lampaki , John Organtzis , Bianca Kathryn Malecki , Sindre Ervik Saetre , Konstantinos Zarogoulidis and Marek Malecki
Research Article: J Nanomedine Biotherapeutic Discov 2014, 4: 128
DOI: 10.4172/2155-983X.1000128
Safeguarding Stem Cell-Based Regenerative Therapy against Iatrogenic Cancerogenesis: Transgenic Expression of DNASE1, DNASE1L3, DNASE2,DFFB Controlled By POLA1 Promoter in Proliferating and Directed Differentiation Resisting Human Autologous Pluripotent Induced Stem Cells Leads to their Death
Marek Malecki, Christine LaVanne, Dominique Alhambra, Chaitanya Dodivenaka, Sarah Nagel and Raf Malecki
Research Article: J Stem Cell Res Ther 2013, S9-005
DOI: 10.4172/2157-7633.S9-005
Eradication of Human Ovarian Cancer Cells by Transgenic Expression of Recombinant DNASE1, DNASE1L3, DNASE2, and DFFB Controlled by EGFR Promoter: Novel Strategy for Targeted Therapy of Cancer?
Marek Malecki, Jessica Dahlke, Melissa Haig, Lynn Wohlwend and Raf Malecki
Research Article: J Genet Syndr Gene Ther 2013, 4: 152
DOI: 10.4172/2157-7412.1000152
Suicide Gene Therapy for Cancer – Current Strategies
Paul Zarogoulidis, Kaid Darwiche, Antonios Sakkas, Lonny Yarmus, Haidong Huang, Qiang Li, Lutz Freitag, Konstantinos Zarogoulidis and Marek Malecki
Review Article: J Genet Syndr Gene Ther 2013, 4: 139
DOI: 10.4172/2157-7412.1000139
Frontiers in Suicide Gene Therapy of Cancer
Marek Malecki
Review Article: J Genet Syndr Gene Ther 2012, 3:119
DOI: 10.4172/2157-7412.1000119
Nuclear Routing Networks Span between Nuclear Pore Complexes and Genomic DNA to Guide Nucleoplasmic Trafficking of Biomolecules
Marek Malecki and Bianca Malecki
Research Article: J Fertiliz In Vitro 2012, 2:112
DOI: 10.4172/2165-7491.1000112
Cancer Suicide Gene Therapy
Marek Malecki
Editorial: J Genet Syndr Gene Ther 2012, 3:e114
DOI: 10.4172/2157-7412.1000e114
Routing of Biomolecules and Transgenes' Vectors in Nuclei of Oocytes
Marek Malecki and Bianca Malecki
Research Article: J Fertiliz In Vitro 2012, 2:108
DOI: 10.4172/2165-7491.1000108
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