alexa Monte S Willis | University of North Carolina at Chapel
ISSN: 2167-1095

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Monte S Willis

Monte S Willis Monte S Willis
Director
Campus Health Services Laboratory
University of North Carolina at Chapel Hill USA
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Biography

Dr. Willis received his MD/PhD training at the University of Nebraska Medical Center (1993-2001).  He is currently a tenure track Associate Professor in the Department of Pathology & Laboratory Medicine at the University of North Carolina at Chapel Hill.  He is Laboratory Director of the UNC Campus Health Services, Assistant Director of the Clinical Chemistry Laboratory at UNC Hospitals, and a principal investigator in the McAllister Heart Institute.  He currently serves as an editorial member of 8 journals, including the American Journal of Pathology, American Journal of Cardiovascular Disease, Journal of Molecular and Cellular Cardiology, and American Journal of Physiology Heart and Circulatory Physiology.  He has authored 140 peer reviewed manuscripts and book chapters and edited 1 book.  He is a fellow of the College of American Pathologists and American Society of Clinical Pathology, and member of the American Heart Association, American Society of Investigative Pathology, and International Society for Heart Research. 

Research Interest

The focus on my laboratory is in investigating the role of the ubiquitin proteasome system in common cardiac and vascular diseases such as heart failure, ischemic heart disease and atherosclerosis.  We have discovered that specific E3 ubiquitin ligases, which tag specific proteins for degradation, interact with a host of intracellular signaling pathways that regulate cardiovascular metabolism and muscle mass in ways that are cardioprotective in disease models in vivo.  We are currently developing ways to regulate these ubiquitin ligases for therapeutic use in pre-clinical models.

 

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