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Dr. Ghosh received his BVSc (DVM equivalent) from WBUAFS, West Bengal, India, his M.S. from University of North Texas, Texas, USA, and his Ph.D from University of Wisconsin-Madison, Madison, USA. His doctoral work used gene and genome-wide analyses to decipher the virulence of Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne’s disease, a chronic enteric infection in ruminants and further understand the mechanisms of bacterial adaptation to infection. His doctoral studies also provided the rational basis for using virulence-attenuated mutant strains of Map to develop improved vaccines that elicit robust immunity. At the end of his graduate studies, he worked at a start-up company, Pan Genome Systems Inc. before joining Harvard Medical School as a Research Fellow.
Dr. Ghosh is a highly-experienced researcher in the fields of microbial pathogenesis and host-pathogen interactions. His current research areas include study of host-pathogen interactions, with an emphasis on elucidating the molecular mechanisms of intracellular pathogenesis using Listeria monocytogenes (Lm) as a model intracellular pathogen. Another aspect of his research interests is to understand fundamental aspects of adaptive immunity and T cell-mediated protection to intracellular pathogens in humans and animals.
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