alexa Vladiamr Litvak | University of Massachusetts
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Vladiamr Litvak

Vladiamr Litvak Vladimir Litvak
Assistant Professor
Department of Microbiology and Physiological Systems
UMass Medical School University of Massachusetts

The innate immune system must tightly regulate the temporal dynamics and the extent of inflammatory responses to promote clearance of invading pathogens without excessive tissue damage. Pathogens are detected by pattern recognition receptors such as the Toll-like receptors (TLRs) which recognize microbial components and activate intracellular signaling pathways leading to the transcriptional induction of genes that are critical for protective inflammatory responses. Systems biology studies have demonstrated that TLR-induced inflammatory responses are controlled by the integration of transcriptional “on” and “off” switches with “amplifiers” and “attenuators”, altogether forming gene regulatory circuits. Dynamic interplay of transcription factors in these circuits determines the transcriptional profile of a target gene and ensures appropriate host response to invading pathogens. However, pathogens are equipped with a wide range of virulence factors to subvert host protective responses and to establish a niche for their survival and proliferation. Virulence factors dynamically interact with host transcription factors and chromatin remodeling proteins to rewire and reprogram host gene regulatory circuits. In my lab we aim at elucidating the mechanisms and consequences of pathogen-induced reprogramming of host gene regulatory networks. Understanding these complex host-pathogen interactions is critical for the discovery of novel antiviral therapies and rational vaccine design and development.


Research Interest

Innate immunity, Systems Immunology

Global Speakers in the subject

Global Experts in the subject

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version