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Metabolomics:Open Access
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Archibald James Mixson

Archibald James Mixson Archibald James Mixson
Associate Professor
Department of Pathology
University of Maryland
Tel. 410- 706-3223
Fax: 410- 706-8414

Dr. James Mixson is an associate professor in the department of Pathology, University of Maryland. He served as an editorial board member for Drugs of Today and for Drugs of the Future. He has also worked as a reviewer for many journals.

Research Interest

Research in his laboratory is directed at developing novel gene therapy polymers as nucleic acid carriers and as antifungal agents. These polymers are comprised of histidines and lysines (HK) and can be varied in their degree of branching complexity.  For nucleic acid delivery, they have used HK peptides to deliver antiangiogenic “nucleic acids” (plasmids, siRNA, DNAzymes) for in vitro or in vivo model systems. Currently, my laboratory is examining the biophysical properties of the interactions of different polymers with nucleic acids and we are correlating these observations with the ability of polymers to transport nucleic acids intracellularly.  In addition to the nucleic acid experiments, present studies are ongoing to test the antifungal efficacy of HK peptides and their synergy with conventional antifungal drugs. Several biotech companies are actively developing these HK inventions as their lead product in areas of cancer therapeutics, wound healing, and antifungal treatments.


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