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Dr. Dominique Belin obtained a PhD in molecular biology. He worked in the Pathology Department of the University of Geneva from 1982 to 2017. He spent one year in the Microbiology Department at Harvard Medical School.
After studying an unusual temperature-sensitive mutant of phage T4, he cloned the murine uPA gene, an actor of extracellular proteolysis. PAI-2, a uPA inhibitor, partitions between the cytoplasm and the extracellular space. This led to studies on protein export, both biochemically and genetically in E. coli. Recently, he studied genes of unknown function in the phage T4 genome. These genes represent the dark matter of the biological universe.
Serine proteases and extracellular proteolysis, Inhibitors of serine proteases (SERPINs), Protein translocation across membranes, Genetics of bacteria and phages
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