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Kartik W Temburnikar received his bachelor’s degree from Institute of Chemical Technology, Mumbai after which he worked in generics research division at Lupin Research Park, Pune. He pursued doctoral research at University of Maryland Baltimore County under Prof. Katherine Seley-Radtke. There he discovered the anitproliferative properties of heterocyclic compounds and synthesized C-nucleosides. Subsequently, he was a Simons Foundation postdoctoral fellow in Prof. John C. Chaput’s research group at Arizona State University pursing research on threose nucleic acids and Origins of Life. Currently, he is in the Department of Pharmacology and Molecular Sciences, at Johns Hopkins School of Medicine, Baltimore. Temburnikar’s broad areas of research include heterocyclic chemistry, drug discovery and nucleic acids research.
Chemical modifications to the structure of nucleosides were employed during my doctoral and postdoctoral research to explore the medicinal and supramolecular properties of modified nucleobases, nucleosides and oligonucleotides. These research activities involved the study of fused pyrimidines expressing novel antiproliferative properties, molecular recognition of sugar modified oligonucleotides and self-assembly of Janus-type modules into supramolecular nanostructures. Currently, I am developing molecular fragments to converge combinatorial chemistry with peptide phosphonate chemistry toward designing new classes of antibacterials. In addition, I am focusing on chemical aspects of drug delivery and formulation of anti-HIV therapies to mitigate the drawbacks of current oral antiretroviral therapy. The outcome of these endeavors will enable discovery of new antimicrobial drugs with better selectivity and clinical utility.
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