alexa
Reach Us +44-2476101207
Editor - Sarbjit Singh | University of Texas at Dallas | 26329
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
 

Sarbjit Singh

Sarbjit Singh Sarbjit Singh,
PhD (Research Associate)
Department of Chemistry,
University of Texas at Dallas,
USA
Biography

Dr. Sarbjit Singh, Research Associate at Department of Chemistry, University of Texas at Dallas, USA. I earned my Ph.D. degree in Chemistry from Guru Nanak Dev University, India, which was accomplished under the supervision of Prof. Swapandeep Singh Chimni and the thesis entitled, “Development of Small Organic Molecules as Catalysts for Asymmetric Organic Transformations.” After earning my PhD degree I worked in a pharmaceutical company for one year where I handled important drug discovery projects and synthesized a library of molecules in each project. The focused diseases were multi-drug-resistant tuberculosis (MDR-TB), type 2 diabetes mellitus (by inhibiting ketohexokinase (KHK)) and Cancer (by inhibiting PI3K/AkT/mTOR pathway). Along with this work I also synthesized some novel analogues of Epicatechin and related polyphenols. I got success to earn one patent from the later work. After working in Pharma Company I moved to Korea and joined Dr. Yongseok Choi’s Lab at Korea University as Research Professor. At Korea University I’ve conducted basic research focused on synthesis of isomeric dioxolane nucleosides using a divergent strategy. In another project, I synthesized a library of oxazolidinone and indole derivatives and evaluated their potential as IL-6 signaling blockers. Interestingly our lead compound potently inhibited IL-6 signaling with IC50 value much better than (+)-Madindoline A, a known inhibitor of IL-6. In Dr. Yongseok Choi’s Lab, I was also team leader of an industrial project under which I designed and synthesized a series of (1S)-(-)-verbenone derivatives and evaluated their insecticidal activities against Plutella xylostella (L.). After working in Dr. Yongseok Choi’s Lab I joined Dongguk University in South Korea as an Assistant Professor (non-tenure track). At Dongguk University I got a chance to work in collaboration with BIOCON Korea in two anti-cancer projects headed by Dr. Kyeong Lee (Director, Open Translational Research Center for Innovative Drug, Dongguk University). In both projects I was responsible for design and synthesis with a team of two PhD and three graduate students. The aim of one project was to control cancer metastasis via inhibition of Lysyl-tRNA synthetase (KRS) and 67 laminin receptors (67-LR) interactions. The drug target in another project was AMIP2-DX-2 which is a splicing variant of tumor suppressor AIMP2. In order to inhibit AMIP-2-DX-2 we synthesized a library of more than 200 molecules and got highly potent leads which displayed excellent potential against chemoresistant epithelial ovarian cancer. Along with industrial work at Dongguk University I also synthesized a series of N-hydroxypyridones derivatives which showed a good potential to protect astrocytes from H2O2 toxicity during the oxidative stress. This work has been published recently. Currently I am working in the department of Chemistry, University of Texas at Dallas. Here I am designing and synthesizing some trisbenazmide having α-helical structure (peptidomimetics) as androgen receptors inhibitors for the treatment of prostate cancer. I am also making a library of hydrazine based compounds which has shown a good potential to inhibit jumonji histone demethylase. Along with this work I am doing solid phase peptide chemistry here. I have synthesized some linear peptides using 2-CTC and rink amide resins.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version