alexa Shu-Yuan Cheng | City University of New York

Journal of Cell Science and Apoptosis
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Shu-Yuan Cheng

Shu-Yuan Cheng Shu-Yuan Cheng Associate Professor, John Jay College of Criminal Justice City University of New York
Biography

I, Shu-Yuan (Demi) Cheng, am Associate Professor of Toxicology at John Jay College. I began my career as a pharmacist. Understanding the toxicity of drugs is essential for a pharmacist. We all know that the right dose can make the difference between a poison and a remedy. Drug-drug interaction is always a big issue for a toxicologist. Due to these reasons, I became interested in divulging the toxic mechanism of drugs that can potentiate or synergize the toxic effect of other drugs. Moreover, being a John Jay Forensic Toxicology professor I am also interested in using new analytical methods for the quantification of drugs in different types of biological specimens. With collaboration with Organic Chemist on cancer research, my research has a new direction on studying the pharmacological mechanism of anti-cancer drugs. I have received several grants from the National Science Foundation, the National Institutes of Health, the Department of Defense, and PSC-CUNY in support of my research.

Research Interest

The focus of my research is on the study as the followings. (1) the epidemiology of marijuana and prescribed opioids in waste water system of New York City by LC-MS/MS --- to understand the usage of marijuana and opioids in NYC area. (2) the cellular toxic responses and mechanism of pesticides (dithiocarbamates) on neuronal cells --- to understand the role of dithiocarbamates in the pathogenesis of neurodegenerative diseases. (3) the pharmacological mechanism of anticancer drugs mitomycin C and its analog on p53 proficient and deficient cells --- to unveil the cell death pathway regulated by mitomycin C and its analog. (4) the biological testing for the potential anti-cancer drugs identified by computational kinase binding analysis --- to reveal the anti-cancer therapeutic activity of existing non-anti-cancer drugs .

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