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Contact Editorial in Chief - Journal of Genetic Syndromes and Gene Therapy Journal
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
Open Access

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Marek Malecki Editor-in-Chief
Marek Malecki
President
Genetic and Biomolecular Engineering PBMEF,
San Francisco, USA
 
Biography

Marek Malecki MD PhD developed a novel cancer suicide gene therapy. He initially developed it for ovarian cancers as the means of protecting women’s fertility and eliminating risks of genetic diseases in the offspring. It is based upon the novel biotechnology, which he invented and patented. He is currently a Visiting Professor at the UW, Madison and PBMEF, San Francisco. He earned MD degree at the Medical Academy, Poznan followed by Residency/Fellowship in Molecular Medicine in Rigshospitalet, Copenhagen. He earned PhD at the Polish Academy of Sciences, Warsaw followed by the EMBO and AAS postdoctoral fellowships in molecular biology at the Austrian Academy of Sciences, Salzburg, ETH, Zurich, Utrecht University, Utrecht, Cancer Center, Vienna, Cancer Center, Amsterdam, Biozentrum, Basel.

 
Research Interest

Cancers of ovaries, cancers of testes, cancer stem cells (CSC), circulating tumor cells (CTCs), genetic disorders, iatrogenic genetic mutations, gene therapy, targeted gene delivery, site specific recombination, biotechnology, synthetically antibodies, synthetically modified nucleic acids, fertility sparing therapy, biobanking, in vitro fertilization.

 
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Jianfeng Lu Editor-in-Chief
Jianfeng Lu
University of Wisconsin-Madison
USA
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Biography

Dr. Jianfeng Lu was born in a small town in China. He likes Biology and Medicine since he was in Mid-school. He treat biology and medicine research as one of the greatest jobs in the world. He is proud of being a bio-medical researcher, because he think through my research, maybe he could do something really good for the whole human beings. Now he is focusing on the research on induced pluripotent stem cells, induced neural cells and neural degeneration diseases. He hopes that he can share the knowledge with the world and make something translated into clinical medicine to help the patients out of pain.

 
Research Interest

During more than ten years of clinical and biomedical study, He gradually focuses his research area in Stem cells and Neurosciences, which he treats as an important and essential component for Regeneration Medicine. As for the Stem cells part, He is interested in generation of pluripotent stem cells (iPSCs), generation of induced neural stem cells (iNP/iNSC) and generation of induced precursors of some neuronal subtypes, such as serotonin neuron precursors (i5-HTP); And at the same time, he is trying his best to uncover the mechanism behind the phenomenon. He took charge in the iPSC core at Waisman center in University of Wisconsin-Madison from 2009 to 2011 and played the role as one of the advisors of iPSC Service in 2012, in which he generated more than 28 iPSC cell lines from different patients, such as Down Syndrome (DS), Spinal Muscular Atrophy (SMA) and Rett Syndrome (RS). They use patients’ iPSC derived neurons or glial cells to compare with the wild type target cells, and then find the differences in phenotypes and functions. With some compounds treatment or genetic modification, he could rescue some important phenotypes in the in vitro system, which potentially could help the discovery of new targets to treat the patients and the screening of new drugs for therapy. They really hope via this approach, we could find some efficient ways to treat the patients with neural degeneration diseases. As for the Neurosciences part, He is interested in neural differentiation and specification. He did some research on mouse embryonic stem cells and its neural differentiation. Through experiments, they found that retinoic acid (RA) could promote neural lineage entry by ESCs in adherent monolayer culture systems and this effect depends on RA signaling and its crosstalk with the ERK and Wnt pathways. Recently, they use human pluripotent stem cells (PSC) to generate many subtypes of neurons and glial cells. Beside the phenotype comparison between normal persons and patients which are mentioned above, they also use these PSC-derived- neurons or glial cells to transplant into the animal models to see the cell-therapy effects, especially for some cell-type deficient neural diseases, such as Parkinson’s disease (PD). He is still learning from others and the work. He hopes one day he could really bring some useful information to those patients and help them to relief some pain.

 
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Yoshiyuki Yamada Editor-in-Chief
Yoshiyuki Yamada
Section Chief
Department of Allergy and Immunology
Gunma Childrens Medical Center
Japan
 
Biography

Yoshiyuki Yamada is Section Chief, Division of Allergy and Immunology, Gunma Childrens Medical Center in Gunma, Japan. He received his MD in Kansai Medical University (1995) and a PhD in Akita University Graduate School of Medicne (2003). He completed his Residency and Clinical Fellowship in Pediatrics, Kansai Medical University (1995-1998). He completed post-doctoral fellowship in Allergy and Immunology, Cincinnati Childrens Hospital Medical Center (2003-2007). He is a recipient of several awards (American Heart Association Ohio Valley Affiliate Postdoctoral Fellowship, Best Abstract Award in 4th Biennial Congress of the Int Eosinophil Society, FIT Best Abstract Award, MAAI interest section American Academy of Allergy, Asthma and Immunology (AAAAI) 2006 and several awards of AAAAI) and several grants including Japanese national one. He is currently an assistant editor of Pediatrics International. Dr. Yamada is a team leader of pediatric eosinophilic esophagitis in Research on Intractable Diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan.

 
Research Interest

Eosinophilic disorders (hypereosinophilic syndromes and eosinophilic gastrointestinal disorders), allergic disorders, laboratory medicine and infectious diseases.

 
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