alexa Elective Termination Decision in Sex Chromosomal Abnormalities-Current Situation in Decision Making Process | Open Access Journals
ISSN: 2161-038X
Reproductive System & Sexual Disorders: Current Research
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Elective Termination Decision in Sex Chromosomal Abnormalities-Current Situation in Decision Making Process

Haluk Akin*

Department of Medical Genetics, Ege University, Turkey

*Corresponding Author:
Haluk Akin
Department of Medical Genetics
Ege University, Turkey
E-mail: [email protected]

Received date: December 18, 2012; Accepted date: December 19, 2012; Published date: December 28, 2012

Citation: Akin H (2012) Elective Termination Decision in Sex Chromosomal Abnormalities-Current Situation in Decision Making Process. Reprod Sys Sexual Disorders 1:e107. doi:10.4172/2161-038X.1000e107

Copyright: © 2012 Akin H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Reproductive System & Sexual Disorders: Current Research

Sex Chromosome Abnormalities (SCAs) are the most common genetic disorder with a frequency of 1/400 or 1/500 live births [1]. Reproductive decisions based on genetic counseling of SCAs are complicated. Prenatally diagnosed diseases with uncertain consequences or moderate severity is the main subject of this complex decision making process. What is the most recent scientific approach in the elective termination of SCAs?

Reproductive decisions post genetic counseling, in all genetic conditions; represent a dynamic interaction between patients, obstetricians and genetic counselors. A limited number of principles, guidelines and standards must be applied when counseling in regard to “testing for fetal genetic disease.” These principles dictate that genetic counseling should be non-directive and unbiased and that parental decisions should be supported regardless of the reproductive choice [2].

Elective termination rates subsequent to prenatal diagnosis differed greatly depending on the sex chromosome abnormality. The primary offender was 45, X (54%), followed by 47, XXY (46%), 47, XYY (29%), and 47, XXX (17%) in a local study [3]. In our recent study, a total of 60 pregnancies (0.80%) with SCA were evaluated. Turner syndrome was the most commonly diagnosed SCA in prenatal diagnosis (60%). The most common reason for referral in relation to pregnancies with Turner syndrome was cystic hygroma observed via ultrasonography. Of 14 pregnancies presenting with a prenatal diagnosis of SCA (Turner syndrome: 7, Klinefelter syndrome: 5, Mosaic Turner syndrome: 2), 12 (85.7%) were terminated. The ratio of SCA in the prenatally diagnosed cases was similar to that reported in the literature. Although the ratio of terminated pregnancies with Turner syndrome was similar to that reported in European countries, all the pregnancies with Klinefelter syndrome chose termination, which showed a regional difference in Turkey [1].

Interestingly, recent studies have revealed a specific, socially functioning, profile of males with SCA with the suggestion being that it presents vulnerability towards autism [4]. Agreements for termination of pregnancy for sex chromosome or moderate handicap anomalies, when the law only permitted termination of pregnancy for serious and incurable fetal anomalies, were motivated by perceived parental suffering, which was considered the priority. These handicaps were not reversible and could quite conceivably have led to more serious incurable disorders. Other studies have also found that decisions for termination of pregnancy in cases of mild and minor congenital abnormalities have often raised major ethical dilemmas and have not always been in accordance with the regional laws [5,6].

Consequently, an elective termination decision, following prenatally diagnosed SCAs and genetic counseling, is still a hotly debated topic which requires tight and insightful collaboration from all parties concerned as well as updated and relevant genetic information.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

  • International Conference on Gynecology and Obstetrics Pathology
    October 23-24, 2017 Orlando, USA
  • 5th International Conference on HIV/AIDS, STDs and STIs
    Nov 13-14, 2017, Las Vegas, Nevada, USA

Article Usage

  • Total views: 11536
  • [From(publication date):
    December-2012 - Oct 24, 2017]
  • Breakdown by view type
  • HTML page views : 7771
  • PDF downloads :3765

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version