Gilbert's syndrome is a common harmless mild disorder in which the liver is unable to properly process the yellowish-brown pigment called bilirubin. Gilbert's syndrome typically does not need treatment, but may affect the toxicity of certain medication. The medical name for this is ‘unconjugated hyperbilirubinemia’.
In GS the mutation causes ‘reduced gene expression’, meaning that it limits production of thespecific UGT enzyme (called UGT1A1) responsible for conjugating bilirubin . Symptoms Tiredness, Mild weakness, Mild tummy (abdominal) pains and mild feeling of sickness (nausea).
Gilbert Syndrome causes the significant morbidity and mortality throughout the world. The incidence of this disease vary among the different population throughout the world. In Finland, Gilbert's Syndrome affects 1-6% of the entire community. Age group between 17-27 years are mostly been affected.