Cancer related to blood cells is called as Leukemia. Under Leukemia condition, bone marrow produces abnormal cancerous blood cells that crowd out the normal and healthy blood cells. Leukemia is of different types based which blood cell type has become cancerous. White blood cells are more to prone to become cancerous than RBCs and platelets. Leukemia can be acute or chronic and Lymphocytic or Myelogenous. It occurs most commonly in adults above 55 years and children younger than 15 years. The treatment methods used depend on the blood cell affected and whether the leukemia is acute or chronic or Lymphocytic or Myelogenous. Chemotherapy is frequently used to treat leukemia.
This population-based study included 225 consecutive patients aged 10-25 years diagnosed with acute lymphoblastic leukemia during 1990-2004. One hundred and twenty-eight patients (10-16 years) were treated with pediatric Nordic (NOPHO) protocols, and 97 patients (17-25 years) with Finnish Leukemia Group National protocols. We characterized the biological subtypes, clinical features and outcome of these patients. For the whole cohort, the remission rate was 96%, 5-year event-free survival 62% and overall survival 72%. The 5-year event-free survival was 67% for the pediatric treatment group and 60% for the adult treatment group (p=n.s.). Patients with inferior outcome were those with a white blood cell count >or= 100 x 10(9)/L, the Philadelphia chromosome and MLL. Good prognostic features were TEL-AML1, hyperdiploidy, and pediatric intermediate risk stratification.