Lichen sclerosus is an uncommon condition that creates patchy, white skin that's thinner than normal. Lichen sclerosus can affect skin anywhere on your body. But it most often involves skin of the vulva, foreskin of the penis or skin around the anus. nflammation and altered fibroblast function in the papillary dermis leads to fibrosis of the upper dermis.
Genital skin and mucosa are affected most frequently, but extragenital lichen sclerosus does occur, and even rare oral presentations are reported. The role that hypoxia and ischemia have in the initial cellular and vascular damage is supported by the finding of increased glut-1 and decreased vascular endothelial growth factor (VEGF) expression in affected skin.
In mainly retrospective studies or studies with only a few years follow-up circumcision is claimed to be curative in most cases of early and intermediate LS in males (nearly 100% in boys), restricted to prepuce and glans (3+ / D). Regression of symptoms is usually seen 4-8 weeks after circumcision; in most 4-6 months later LS has healed, it may, however, take up to 2 years. Good long-term follow-up studies (more than 10 years) are lacking therefore the rate of recurrences years after circumcision remains undetermined.