alexa Lynch syndrome | Finland| PDF | PPT| Case Reports | Symptoms | Treatment

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Lynch Syndrome

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  • Lynch syndrome

    Pathophysiology
    Lynch syndrome is the familial clustering of colorectal and endometrial cancers. This syndrome is passed in an autosomal dominant fashion within families with defective mismatch repair as the genetic basis for cancer development in these patients.

  • Lynch syndrome

    Statistics
    The disease history and cause of death of all the deceased, tested mutation carriers and their mutation negative relatives in the Finnish LS families (N = 179) was examined utilizing hospital records and relevant national registries. Out of 1069 mutation carriers 151 had succumbed; 97 (64 %) from cancer. Out of 1146 mutation-negative family 44 members had died; 11 (25 %) of them from cancer.

  • Lynch syndrome

    Treatment
    Surgery for Lynch syndrome colon cancer is more likely to involve the removal of more of the colon, since people with Lynch syndrome have a high risk of developing additional colon cancer in the future.

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