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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous glomerulonephritis (MGN) is a slowly progressive disease of the kidney affecting mostly patients between ages of 30 and 50 years, usually Caucasian. MGN is more commonly a primary or idiopathic disease, but it also appears like a disease secondary to other conditions, mainly infections, neoplasms and systemic lupus erythematosus (SLE).

  • Membranous nephropathy

    Disease pathophysiology:

    In membranous nephropathy the filtering layer becomes thickened and there is a protein leak into the urine. Other things can cause this too, so the diagnosis of membranous nephropathy can be only be made by a kidney biopsy. It is sometimes called membranous nephritis or membranous glomerulonephritis.

     

  • Membranous nephropathy

    Disease statistics: 

    Histopathologic findings do not allow a differentiation between primary or secondary forms, nevertheless, some microscopic characteristics (hypercellularity, crescents) and immunopathologic findings (complement deposits that indicate activation of the classic pathway: C1q, C4) permit suspect secondary forms

     

  • Membranous nephropathy

    Disease treatment:

    Characteristically, total plasma cholesterol and triglyceride levels are elevated. Increased lipid levels contribute to an increased risk of coronary disease in nephrotic patients. Elevated lipids may also adversely affect renal function. Therefore, the use of statins is appropriate in patients with prolonged elevation in urine protein excretion and secondary hyperlipidemia

     

  • Membranous nephropathy

    Major research on disease:

    Over the last four years, two independent studies suggested that PLA2R1 plays a role in cancer as a tumor gene suppressor and is the major target antigen of auto-immune antibodies involved in idiopathic membranous nephropathy, a severe human kidney disease. These novel findings shed light on PLA2R1 and pave the way for its use as a reliable biomarker and an attractive therapeutic target in these diseases.

     

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