Sclerosing mesenteritis is part of a spectrum (including mesenteric lipodystrophy and mesenteric panniculitis) of idiopathic primary inflammatory and fibrotic processes that affect the mesentery. Pathophysiologically, these processes may affect the integrity of the gastrointestinal lumen and mesenteric vessels by a mass effect.Sclerosing mesenteritis can cause abdominal pain, bloating and diarrhea. In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through your digestive tract. Surgery may be necessary in this situation.
sclerosing mesenteritis is asymptomatic, gastrointestinal symptoms such as abdominal pain, nausea/vomiting, bloating, loss of appetite, weight loss and diarrhea or constipation, Occasionally, intermittent partial bowel obstruction is encountered. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.
Includes abdominal surgery or trauma , autoimmunity , paraneoplastic syndrome, ischaemic injury and infection.small bowel mesentery is affected in most cases although the sigmoid mesocolon and omentum can also be occasionally be involved. The disease includes three stages. Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat. Stage-2: mesenteric panniculitis, inflammatory reaction. Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.