Stickler syndrome is a group of hereditary conditions characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems. This is caused by underdeveloped bones in the middle of the face, including the cheekbones and the bridge of the nose. Robin sequence includes an opening in the roof of the mouth, a tongue that is placed further back than normal, and a small lower jaw. It is a sex independent autosomal dominant trait meaning a person with the syndrome has a 50% chance of passing it on to each child.
Individuals with Stickler syndrome experience a range of signs and symptoms. Some people have no signs and symptoms; others have some or all of the features described below. In addition, each feature of this syndrome may vary from subtle to severe. A characteristic feature of Stickler syndrome is a somewhat flattened facial appearance. A particular group of physical features, called the Pierre Robin sequence, is common in children with Stickler syndrome. Children with a cleft palate are also prone to ear infections and occasionally swallowing difficulties.
The patients with Stickler's syndrome consisted of 21 (42%) women and 29 (58%) men, with a mean age of 29.56 years. Of the 50 patients, 34 (68%) had traumatic and 16 (32%) had spontaneous Stickler's syndrome. Of traumatic Stickler's syndrome group 24 (70.6%) were men and 10 (29.4%) were women. Stickler's syndrome was more common in the temporal areas than other areas (40.5%)