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Typhoid fever usually is caused by Salmonellae typhi bacteria. Typhoid fever is contracted by the ingestion of contaminated food or water. Diagnosis of typhoid fever is made when the Salmonella bacteria is detected with a stool culture. Typhoid fever is treated with antibiotics. Typhoid fever symptoms are poor appetite, headaches, generalized aches and pains, fever, and lethargy. The incidence ofTyphoid fever in Finland was 17 cases in 1988, 2 in 1999, 275 during 2004 to 2005. 1,875 cases were reported during January 20008 to 2012 in these case 57% are males with median age 25 years. 11 cases are reported in Northern division in 2003, 11 in 2014, 125 in 2005 and 113 during January to August 2006.
Several antibiotics are effective for the treatment of typhoid fever. Chloramphenicol was the original drug of choice for many years. Because of rare serious side effects, chloramphenicol has been replaced by other effective antibiotics. The choice of antibiotics is guided by identifying the geographic region where the infection was contracted (certain strains from South America show a significant resistance to some antibiotics.) If relapses occur, patients are retreated with antibiotics. Researches focusing on Comparative genomics study for identification of putative drug targets in Salmonella typhi Type 2.
