Alcoholic hepatitis is a syndrome of progressive inflammatory liver injury associated with long-term heavy intake of ethanol. Symptoms are Patients who are severely affected present with sub-acute onset of fever, hepatomegaly, Leukocytosis, marked impairment of liver function (e.g., jaundice, coagulopathy), and manifestations of portal hypertension (e.g., ascites, hepatic encephalopathy, variceal haemorrhage).
The diagnosis of alcoholic hepatitis is straightforward and requires no further diagnostic studies in patients presenting with a history of alcohol abuse, typical symptoms and physical findings, evidence of liver functional impairment, and compatible liver enzyme levels. In milder cases of alcoholic hepatitis, a mild elevation of the aspartate aminotransferase (AST) level may be the only diagnostic clue.
Treatment with the steroid prednisolone reduced 28-day mortality in patients with severe alcoholic hepatitis, while treatment with the oral phosphodiesterase inhibitor pentoxifylline did not, according to the results of a study involving 1,103 subjects. There was no difference in mortality rates between the two treatments at on