This virus increases the human infection that spreads from domestic animals like goats, camels, sheeps and also when bitten by a tick, handling raw meat products, drinking unpasteurized milk which.AHFV is caused by Alkhurma hemorrhagic fever virus which is a tick-borne virus of the Flavivirus family that is initially isolated in 1995 in Saudi Arabia and is a variant of Kyasanur Forest Disease.No human-to-human transmission of AHF can be documented.
The disease presents initially with non-specific flu-like symptoms, including fever, anorexia, general malaise, diarrhea, and vomiting and in some cases it includes neurologic and hemorrhagic symptoms in severe form. Alkhurma hemorrhagic fever, with fatality rates up to 25%, have been documented and this virus is mostly occurred in Saudi Arabia and Egypt. Later it was spread to other countries like Italy, Australia etc.
Patients receive supportive therapy that balances the patient’s fluid and electrolytes, maintaining oxygen status and blood pressure, and treatment for any complications. The case-fatality rate is >30%, which makes AHFV one of the most deadly flaviviruses. Pairwise distance comparison with AHFV prototype strain 1176 sequence showed 0.80% and 0.70% divergence at the nucleotide and amino acid level, respectively.