Arteriovenous malformation is an congenital disorder of blood vessels in the brain, brainstem, or spinal cord that is characterized by a complex, tangled web of abnormal arteries and veins connected by one or more fistulas. Arteriovenous malformations are blood vessel defects that occur before birth when the fetus is growing in the uterus. The blood vessels appear as a tangled mass of arteries and veins. They do not possess the capillary bed which normally exists in the common area where the arteries and veins lie in close proximity. An arteriovenous malformation may hemorrhage, or bleed, leading to serious complications that can be life-threatening.
Natural history of AVM hemorrhage, genetic and expression studies of AVM susceptibility and hemorrhage, and strategies for development of a brain AVM model in adult mice. Symptoms of AVM vary according to the location of the malformation. Roughly 88% of people affected with AVM are asymptomatic; often the malformation is discovered as part of an autopsy or during treatment of an unrelated disorder in rare cases its expansion or a micro-bleed from an AVM in the brain can cause epilepsy, neurological deficit or pain.
The estimated detection rate of AVM in the US general population is 1.4/100,000 per year. This is approximately one fifth to one seventh the incidence of intracranial aneurysms. An estimated 300,000 Americans have AVMs, of whom 12% will exhibit symptoms of greatly varying severity.