Dupuytren’s contracture is a hand deformity that usually develops over years. The condition affects a layer of tissue that lies under the skin of your palm. Knots of tissue form under the skin — eventually creating a thick cord that can pull one or more fingers into a bent position.
The affected fingers can't be straightened completely, which can complicate everyday activities such as placing your hands in your pockets, putting on gloves or shaking hands.The basic pathophysiology involves fibroblast proliferation, and collagen deposition leading to contractures of the palmar fascia.
One or both hands may be affected. The ring finger is affected most often, followed by the little, middle, and index fingers. A small, nodule or lump develops in the tissue below the skin on the palm side of the hand. Over time, it thickens into a cord-like band. Usually, there is no pain. In rare cases, the tendons or joints become inflamed and painful. Other possible symptoms are itching, pressure, burning, or tension. As time passes, it becomes difficult to extend or straighten the fingers. In severe cases, straightening them is impossible.
The doctor will examine your hands. Diagnosis can usually be made from the telltale signs of the condition. Other tests are rarely needed.
Doctor may recommend treatment that involves injecting medicine or a substance into the scarred or fibrous tissue:
Studying the epidemiology of Dupuytren's disease allows the identification of populations at risk and may point to inferences regarding etiology. Data suggest the highest prevalence of the disease occurs in people of northern European stock. However, the disease does occur in nearly all populations examined. Dupuytren's disease occurs more frequently in men than women and becomes symptomatic approximately 10 years earlier in the lives of men than in women. Dupuytren's disease has been associated with a number of other diseases including seizure disorders, alcoholism, diabetes mellitus, and cigarette smoking. There is conflicting evidence as to whether manual labor or HIV seropositivity increases the prevalence of the disorder