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Fibromuscular Dysplasia

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  • Fibromuscular Dysplasia

    Fibromuscular dysplasia (FMD) is a rare medical condition. Patients with FMD have abnormal cellular growth in the walls of their medium and large arteries. This can cause the arteries with the abnormal growth to look beaded. The arteries may also become narrow (stenosis).

    FMD is a predisposing factor in 15% of spontaneous cervical carotid dissections. Dissections in FMD are more commonly multiple than in patients without an identified underlying arteriopathy. FMD lesions likely predispose the artery to dissection through weakening of the arterial wall. Although the multiple manifestations of a structural arteriopathy in FMD hint of a genetic cause, such as collagen or elastin mutation, epidemiologic data suggesting familial transmission are generally weak.

  • Fibromuscular Dysplasia

    Symptoms:

    • Headache
    • Dizziness
    • Blurred vision or temporary loss of vision
    • Neck pain
    • Chronic headaches
    • Facial weakness or numbness
    • Abdominal pain after eating
    • Unintended weight loss
    • High blood pressure
    • Tissue damage in your kidney (ischemic renal atrophy)
    • Chronic kidney failure, rarely
  • Fibromuscular Dysplasia

    Diagnostic test:

    • Catheter-based angiography.
    • Doppler ultrasound.
    • Computerized tomography (CT) angiogram
    • Magnetic resonance imaging (MRI).
  • Fibromuscular Dysplasia

    Treatment:

    • Percutaneous transluminal renal angioplasty (PTRA)
    • Surgical revascularization
    • Drugs: Angiotensin-converting enzyme (ACE) inhibitors, Angiotensin II receptor blockers, Diuretics such as hydrochlorothiazide, Calcium channel blockers such as amlodipine.

    Statistics:

    FMD occurs more frequently in women, at a ratio of approximately 3:1 to 4:1. FMD most commonly presents in young to middle-aged adults. One angiographic series found a mean age of 48 years with a range of 24-70 years. Cases have even been described in the pediatric population, including infantile-onset cases.

 

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