alexa Lynch syndrome | France| PDF | PPT| Case Reports | Symptoms | Treatment

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Lynch Syndrome

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  • Lynch syndrome

    Pathophysiology
    Lynch syndrome is the familial clustering of colorectal and endometrial cancers. This syndrome is passed in an autosomal dominant fashion within families with defective mismatch repair as the genetic basis for cancer development in these patients.

  • Lynch syndrome

    Statistics
    MSH6 mutations are associated with markedly lower cancer risks than MLH1 or MSH2 mutations. Lifetime ovarian and endometrial cancer risks associated with MLH1 or MSH2 mutations were high but do not increase appreciably until after the age of 40 years.

  • Lynch syndrome

    Treatment
    Surgery for Lynch syndrome colon cancer is more likely to involve the removal of more of the colon, since people with Lynch syndrome have a high risk of developing additional colon cancer in the future.

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