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Malignant Peripheral Nerve Sheath Tumors
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Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas on peripheral nerves or nerve sheath. These MPNSTs can occur on any cell type and differs from one to other. A sarcoma is regarded as MPNST only when it is raised on the peripheral nerve or it exists on neurofibroma. MPNSTs usually present as an enlarging palpable mass. Pain is a variable complaint.
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Rapid enlargement occurs more often in the setting of NF1 and should raise concern for malignant degeneration of a neurofibroma. In France The prevalence of malignant peripheral nerve sheath tumor (MPNST) among the general population is only 0.001%.
Expert PPTs
- Jun Yang
Histopathology and pathogenesis of digestive system and Female genital and breast tumors
PPT Version | PDF Version - Zhen Yuan
Molecular imaging
PPT Version | PDF Version - Mohammad Reza Daliri
Cognitive Neuroscience
PPT Version | PDF Version - Aruna Turaka
Intensity modulated radiation therapy
PPT Version | PDF Version - Raymond Chong
Neurological disorders
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Speaker PPTs
- Marwan Ahmed
Risk factors for metformin-induced vitamin B12 deficiency and its association with peripheral neuropathy in T2DM
PPT Version | PDF Version - Rajashree Khot
Vitamin D deficiency in diabetic peripheral neuropathy: Prevalence, repletion and treatment outcomes
PPT Version | PDF Version - Alex Bekker
Alex-Bekker-Rutgers-New-Jersey-Medical-School-USA- Perioperative-Stroke
PPT Version | PDF Version - Emanuele Corongiu
Role of percutaneous tibial nerve stimulation in the treatment of neurogenic overactive bladder syndrome.
PPT Version | PDF Version - Yosef Yarden
Classically, the 3âuntranslated region (3âUTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3âUTR alone, without all other elements in mRNA such as 5âUTR and coding region. The importance of independent 3âUTR RNA (referred as I3âUTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3âUTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3âUTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3âUTR were important for its tumor suppression activity. Then, the C/EBP 3âUTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3âUTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3âUTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990âs to 2000âs, world scientists found several 3âUTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3âUTR regions, although the existence of their transcribed products as independent 3âUTR RNAs is still to be confirmed. Our studies indicate that the independent 3âUTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
PPT Version | PDF Version - Alex Soltermann
Lung neuroendocrine tumors: Correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN
PPT Version | PDF Version - Shivanand Reddy
Relation between low serum testosterone level and peripheral arterial disease in men and clinical evaluation of effect of testosterone administration
PPT Version | PDF Version - Marie Schneider
Regenerative Potential of Outer Root Sheath Melanocytes in Tissue Grafts
PPT Version | PDF Version - Lourdes Cortes-Dericks
ALDHhigh/CD44+ putative cancer stem cell population as therapeutic target in malignant pleural mesothelioma
PPT Version | PDF Version - Jim Klostergaard
Magnetic vectoring for drug delivery to tumors: Past, present and is there a future?
PPT Version | PDF Version