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Marburg Virus | France| PDF | PPT| Case Reports | Symptoms | Treatment

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Marburg Virus

  • Marburg Virus

    Marburg hemorrhagic fever (Marburg HF) is a rare but severe hemorrhagic fever which affects both humans and non-human primates. Marburg HF is caused by Marburg virus, a genetically unique zoonotic (or, animal-borne) RNA virus of the filovirus family. The five species of Ebola virus are the only other known members of the filovirus family.

    The reservoir host of Marburg virus is the African fruit bat, Rousettus aegyptiacus. Fruit bats infected with Marburg virus do not to show obvious signs of illness. Primates (including humans) can become infected with Marburg virus, and may develop serious disease with high mortality. The Marburg virus is transmitted by direct contact with the blood, body fluids and tissues of infected persons. Transmission of the Marburg virus also occurred by handling ill or dead infected wild animals (monkeys, fruit bats).

  • Marburg Virus

    Symptoms:

    The onset of illness is sudden, with:

    • severe headache
    • malaise
    • high fever
    • progressive and rapid debilitation

    By about the third day symptoms include:

    • watery diarrhoea
    • abdominal pain
    • cramping
    • nausea
    • vomiting
  • Marburg Virus

    Diagnostic test:

    • Antigen-capture enzyme-linked immunosorbent assay (ELISA) testing,
    • polymerase chain reaction (PCR), and
    • IgM-capture ELISA can be used to confirm a case of Marburg HF within a few days of symptom onset.
    • Virus isolation may also be performed but should only be done in a high containment laboratory with good laboratory practices.
  • Marburg Virus

    Treatment:

    There is no specific treatment available for Marburg virus disease. Patients receive supportive therapy, including:

    • balancing fluids and electrolytes
    • maintaining oxygen status and blood pressure
    • replacing lost blood and clotting factors

    Statistics:

    First outbreak of Marburg hemorrhagic fever occurred in Europe. The source of primary infection during this outbreak was exposure to tissues and blood from African green monkeys imported from Uganda for use in the pharmaceutical industry. In total, the number of known MHF cases is approximately 450.

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