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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephritis
     is one of a group of conditions called ‘glomerulonephritis’, where the immune system damages the kidney.Nephropathy, nephritis or glomerulonephritis are all used, but they all mean the same. Hyperlipidemia so commonly complicates heavy proteinuria that it is part of the definition the nephrotic syndrome. 

  • Membranous nephropathy

    Disease pathophysiology: 

    The Heymann model of experimental membranous nephropathy in rats, which closely mimics the human disease, suggests that the highly specialized and terminally differentiated glomerular epithelial cell or podocyte is the target of injury.

  • Membranous nephropathy

    Disease statistics:

    1-10 per 100,000 person-years. Prevalence: 20-70 per 100,000. Strongest risk factor: women 2-3x higher incidence and prevalence rates. In approximately 25% of cases the disease is secondary, being greater the percentage in children and elderly patients. 

  • Membranous nephropathy

    Disease treatment: 

    The six month treatment involves alternate months of steroids (into a vein initially and then by mouth) andcyclophosphamide tablets (a powerful immunosuppressant). You will also receive tablets to protect you from some of the possible drugside effects. You will collect your treatment once a month from the CAPD Unit on Albert Ward and be seen monthly in the outpatients clinic, with regular blood tests.

  • Membranous nephropathy

    Major research on disease:

    An international team of researchers from France, Germany, and the US have identified a protein that turns a person's immune system against itself in a form of kidney disease called membranous nephropathy (MN). The new research was presented at ASN Kidney Week 2014 in Philadelphia and published online in the New England Journal of Medicine.

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