Rabies Virus can ready to reproduce in muscle and afterward ties to nicotinic acetylcholine receptors at neuromuscular intersection. Infection goes inside of axons in fringe nerves through retrograde quick axonal transport and Replication in engine neurons in spinal string and neighborhood dorsal root ganglia and fast rising to cerebrum. The primary tainted regions at mind neurons with neuronal brokenness.
In France mostly it is like complete pre-exposure series consists of three doses of vaccine injected into the deltoid muscle on days 0, 7, and 21 or 28. The vaccines used for pre-exposure and post-exposure vaccination are the same, but the immunization pattern is different. Even when pre-exposure vaccine has been received, urgent medical advice should be sought after any animal or bat bite.
Since 2009, the site has provided information on progress made in implementation of the 5-year (2009–2013), In France at the time of 1988–1993 the programme conducted under Post-exposure prophylaxis, preventive vaccination of cattle, dogs and cats, oral rabies vaccination and the cost of the programme is 261 (million US$). The last statistic rate of rabies vaccine aware is about 98%.