Sclerosing mesenteritis occurs when the tissue (mesentery) that holds the small intestines in place becomes inflamed and forms scar tissue. Sclerosing mesenteritis is rare, and it's not clear what causes it.
Tests and procedures used to diagnose sclerosing mesenteritis include. 1. Physical exam: sclerosing mesenteritis often forms a mass in upper abdomen that can be felt during a physical exam. 2. Imaging tests: Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography or magnetic resonance imaging. 3. Biopsy: Removing a sample of tissue for testing.
Glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs.Several other medications such as azathioprine, colchicine, Cyclophosphamide and thalidomide.
In a five-year follow-up report of 40 patients with mesenteric Sclerosing mesenteritis, 40 percent were alive, and in those who died, one-half of the deaths were due to malignancy (50 percent carcinoma, 50 percent lymphoma) In another series, 12 percent of patients developed malignancy, including lymphoma, carcinoid syndrome, lung adenocarcinoma, and mesothelioma. Fulminant cases of sclerosing mesenteritis have been reported and are largely due to complications of intestinal obstruction.