Definition: Small vessel disease is a condition in which the small arteries in the heart become narrowed. Small vessel disease causes signs and symptoms of heart disease, such as chest pain (angina). Small vessel disease is sometimes called coronary microvascular disease or small vessel heart disease. It's usually diagnosed after a doctor checks for blockages in the main arteries of the heart but finds little or no narrowing in the large vessels, even though your symptoms persist.
Symptoms: Chest pain, squeezing or discomfort, Chest pain associated with discomfort in your left arm or jaw, Chest pain that worsens with daily activities and at times of emotional stress, Neck, shoulder, upper back or abdominal discomfort, Shortness of breath, Unusual fatigue, A loss of energy, Trouble sleeping.
Statistics: Diffuse white matter hyperintensities were observed on T2-weighted magnetic resonance imaging (MRI) in six individuals. In contrast with MRI results in the father and paternal uncle of the proband who were hypertensive, white matter lesions were extensive in the mother who had no vascular risk factor. MRI data in four asymptomatic family members together with the results in the two initial cases were suggestive of an underlying hereditary small vessel disease of the brain. Skin biopsy and NOTCH3 gene mutation screening were negative. Haplotype analysis excluded the NOTCH3 locus.