Typhus fever is arguably the most historically important disease you've never heard of. In this lesson, I will attempt to shed some light on this deadly disease and provide some basics on the bacterium that causes it: Rickettsia.Small blood vessels are the sites of the characteristic pathologic lesions. Rickettsiae propagate within damaged endothelial cells, and vessels may become blocked by thrombi, producing vasculitis in the skin, subcutaneous tissues, CNS, lungs, heart, kidneys, liver, and spleen. Disseminated intravascular coagulation often occurs in severely ill patients.
In the France, about 2,673 cases of Typhus fever are reported in each year. Almost 10% of the France population is suffering with Typhus fever, a disease caused by bacteria called Rickettsia typhi or bacteria called Rickettsia felis.Doxycyclineis the treatment of choice. Fluoroquinolones or chloramphenicol are alternative drugs for therapy. Antibiotic therapy should be initiated when this disease is suspected without waiting for test results.