Pathophysiology: Viral hemorrhagic fever (VHFs) is a general term to severe group of illness caused by RNA viruses from several viral families. It is a severe multisystem syndrome caused by infectious viruses which lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding.VHF is caused by viruses of four families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses.
Disease Statistics: Cases of Ebola virus has been suspected frequently in past recent years in France. Teams are analyzing the cases of Ebola Viruses from end of November 2014.
Treatment: Patients usually receive supportive therapy but as such there are no other treatment or established cure for VHFs. Ribavirin, an anti-viral drug, have been effective in treating some individuals with Lassa fever or HFRS. Treatment with convalescent-phase plasma has been used with success in some patients with Argentine hemorrhagic fever.
Research: The research group involved the National Reference Center for Viral Hemorrhagic Fevers, hosted by the Biology of Viral Emerging Infections Unit at the Institut Pasteur in Lyon, directed by Sylvain Baize, has been designated by the French Ministry of Health and tasked with contributing to diagnosis and epidemiological surveillance efforts for viral hemorrhagic fevers, in close collaboration with the French National Institute for Health Monitoring (InVS).