alexa G-quadruplexes|omicsgroup|Molecular Biology

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G-Quadruplexes

In the past few decades a large number of scientific papers, both computational and experimental in vitro and in vivo, have demonstrated that G-rich DNA sequences can fold as intrastrand quadruple helix structures called G-quadruplexes or G4-DNA. G4-DNA is stabilized by G-quartets, planar arrays of four guanines paired by Hoogsteen hydrogen bonding, and monovalent alkali cation, K+ or Na+, located in the central cavity of the structure. In the human genome the sites that can potentially form G4- DNA are estimated to be more than 3,00,000. They are not randomly distributed, but located preferentially in repetitive genomic sequences such as the telomeres, ribosomal DNA and the immunoglobulin heavy-chain switch regions. SScholarly journals which publish original scientific work are called as research articles and those which revise already existing data in brief are known as review articles. Both these articles follow a formal specific and unambiguous format to avoid bias and confusion. All the data like graphs, reports and tables are presented to support the content. Usually advertising is not seen but can be added only if it is relevant to the field. OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the dramatic effort of world quality editorial board members. Molecular Biology publishes original research, review, and Short communication, Case study in the field of molecular biology.
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Last date updated on June, 2014

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