|The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Cancer and its treatment are an immense burden not only on the individual patient but also on the entire healthcare system. A major limitation of conventional chemotherapies used in cancer treatments today are low therapeutic indices and side effects that result from drug effects on normal tissues (off target). One of the most innovative approaches to developing antineoplastic agents with increased tumor selectivity is the use of suicide gene therapy. Suicide gene therapy involves delivering a gene product in proximity to the targeted cancer tissue through various targeted delivery methods followed by tissue/tumor-specific expression of the gene product which then converts a systemically available pro-drug into an active drug within the tumor locale. In suicide gene therapy, gap junctions allow local diffusion of the active drug resulting in an enhanced effect. In addition, a bystander effect can be mediated through the enhanced immune response as an effect of the resulting cancer necrosis which can sensitize the immune system independently from the expressed suicide gene. Suicide gene therapy is based on the introduction of genes into tumor tissue which ultimately results in cancer cell death. (Rajab K, Nelson P, Keung EZ, Conrad C, Suicide Gene Therapy against Cancer)