Diabetes was induced in CD1 mice by Streptozotocin (STZ), as described previously. STZ (Sigma-Aldrich) was dissolved in 50 mM sodium citrate buffer (pH 4.5) and a final concentration of 6 mg/ ml was made. The animals were injected intraperitoneally at a dose of 45 mg/kg/day. Treatment was repeated for 5 consecutive days. Blood glucose level was measured, in non fasted animals on alternate days and mice were considered diabetic when blood glucose levels exceeded 250 mg/dL. Serum biochemical variables like CHO and TGY had significant effect with increase in db/db mice on the other hand there were significant decrease in CHO and TGY in STZ induced CD1 mice. The liver enzymes AST and ALT showed significant decrease in STZ induced CD1 mice as reported previously on other species after overnight fasting but there were no significant changes in db/db mice.
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Last date updated on September, 2014