|Methylation is known to regulate biological processes and alterations in methylation patterns have been associated with a variety of diseases. Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an unexplained disorder associated with immunological and molecular changes. CD4+T cells specifically, regulatory T cells (Tregs) have been implicated in CFS/ME patients where significant increases in Tregs have been observed. CFS/ME involves disruption to immunological processes including reduced cytotoxic activity and elevated levels of regulatory T cells. CFS/ME patients may exhibit differential expression in genes that regulate various physiological processes known to be abnormal in CFS/ME.
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