Reach Us +44-1202-068036
Genetic and Metabolism come in the Hot Spot | OMICS International
ISSN: 2157-7609
Journal of Drug Metabolism & Toxicology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Genetic and Metabolism come in the Hot Spot

Rizzolio Flavio and Toffoli Giuseppe*

CRO-National Cancer Institute, 33081 AVIANO – PN, Italy

*Corresponding Author:
Toffoli Giuseppe, MD
Director of Experimental and Clinical Pharmacology Unit
CRO-National Cancer Institute
33081 AVIANO - PN, Italy
Tel: +39-0434-659612 (659667)
Fax: +39-0434-659799
E-mail: [email protected]

Received date: October 12, 2013; Accepted date: October 15, 2013; Published date: October 18, 2013

Citation: Giuseppe T (2013) Genetic and Metabolism come in the Hot Spot. J Drug Metab Toxicol 4:e121. doi: 10.4172/2157-7609.1000e121

Copyright: © 2013 Giuseppe T. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Drug Metabolism & Toxicology

Highlights from the current issue of the Journal of Drug Metabolism & Toxicology focus on different special issues involving important pathologies as nephropathies, neurodegenerative diseases and cancer.

In Biotransformations & Toxicology, Maso et al. [1] face the problem of sex-related differences in nephrotoxic substances. The authors find that sex hormones influence the renal oxidative metabolism, suggesting that a complex mechanism is involved for toxicity of xenobiotic substances.

In Genetic Toxicology and Toxicogenomics, it is tackled the problem of inactivation of estrogens and their metabolites by the UGTs enzymes. Starlard-Davenport et al. [2] demonstrated that UGT1A1 mRNA down-regulation was strongly correlated with postmenopausal status in breast cancer versus controls, suggesting that further analyses are necessary to better define the clinical implications.

In Heavy Metal Drug Toxicology, the review from Arroyo et al. [3] presents the current state of knowledge related to the cellular mechanisms of Cd toxicity in the liver from the molecular mechanisms to the effect on the physiology of the cells. In the second review from Neal and Guilarte, it is summarized the toxicokinetics of Pb2+and Mn, the neurotoxic mechanisms, and gives a general overview of heavy metals problems for public health. The research article form Lowry et al. [4] studied the effect of lead on Cytochromes P450 in a small number of children. The authors conclude that low blood lead levels have no effect on the CYP drug metabolizing enzymes. Further studies are needed to assess the effect from higher blood lead levels. Finally, Khargharia et al., [5] reported a study on disposition kinetics of amoxicillin in healthy as well as nephropathy black-Bengal goats. Authors suggested that the usage of amoxicillin should not be recommended in nephropathic condition as well as for consecutive long-term administration.

In Mechanisms in Free Radical Metabolomics, two reviews from Amin and Reed and Sellers [6,7] discuss the possibility to use freeradicals modulating agents and beyond with standard anti-cancer therapies in Alzheimer’s disease and cancer.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 11962
  • [From(publication date):
    December-2013 - Dec 13, 2018]
  • Breakdown by view type
  • HTML page views : 8184
  • PDF downloads : 3778

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry


[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7