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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy
     (MN) is among the most common causes of the nephrotic syndrome in nondiabetic adults, accounting for up to one-third of biopsy diagnoses in some regions. MGN may place you at risk for developing blood clots, and your doctor may prescribe blood-thinning medications to control this risk.

  • Membranous nephropathy

    Disease pathophysiology: 

    The presence of immunoglobulins (Igs) and complement components in capillary walls (subepithelial), and the morphologic and immunopathologic similarities between the experimental MGN and immunological glomerular diseases support the concept that MGN is an immune complexes mediated disease. The etiology and origin of the antigens that cause MGN are not known. 

  • Membranous nephropathy

    Disease statistics: 

    At one time,it was the most common biopsy diagnosis in adults (particularly over age 40 years) with the nephrotic syndrome, but the relative frequency of MN on kidney biopsy has declined to between 15 and 33 percent since 1990 [3-6]. This reflects at least in part an increase in the relative frequency with which focal segmental glomerulosclerosis is identified in black and Hispanic patients with nephrotic syndrome.

  • Membranous nephropathy

    Disease treatment: 

    There is no cure for MGN. Treatment focuses on controlling and reducing the symptoms of the disease. You may need to make changes in your diet, including reducing your salt and protein intake. You may also need to take medication to help control your blood pressure. Drugs known as corticosteroids may be prescribed by your doctor to suppress (quiet) your immune system. Water pills or diuretics may be used to reduce swelling. 

  • Membranous nephropathy

    Major research on disease:

    Establish and harmonize a large database of deeply phenotyped patients and related bioresources Identify pathogenic B-cell epitopes, novel antigens and gene variants responsible for disease initiation, progression and recurrence in the graft Characterize T-cell epitopes, T-cell regulation and triggering events involved in disease initiation, remission and recurrence 

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  • Hayam I Gad
    Effects of Pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of Diabetic nephropathy in an experimental model of diabetic renal disease
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