(MN) is among the most common causes of the in nondiabetic adults, accounting for up to one-third of biopsy diagnoses in some regions. MGN may place you at risk for developing blood clots, and your doctor may prescribe blood-thinning medications to control this risk.
The presence of immunoglobulins (Igs) and complement components in capillary walls (subepithelial), and the morphologic and immunopathologic similarities between the experimental MGN andsupport the concept that MGN is an immune complexes mediated disease. The etiology and origin of the antigens that cause MGN are not known.
At one time,it was the most common biopsy diagnosis in adults (particularly over age 40 years) with the nephrotic syndrome, but the relative frequency of MN on kidney biopsy has declined to between 15 and 33 percent since 1990 [3-6]. This reflects at least in part an increase in the relative frequency with which is identified in black and patients with nephrotic syndrome.
There is no cure for MGN. Treatment focuses on controlling and reducing the symptoms of the disease. You may need to make changes in your diet, including reducing your salt and protein intake. You may also need to take medication to help control your blood pressure. Drugs known as may be prescribed by your doctor to suppress (quiet) your immune system. Water pills or may be used to reduce swelling.
Establish and harmonize a large database of deeply phenotyped patients and related Identify pathogenic B-cell epitopes, novel antigens and gene variants responsible for disease initiation, progression and recurrence in the graft Characterize T-cell epitopes, T-cell regulation and triggering events involved in disease initiation, remission and recurrence