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Narcolepsy

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  • Narcolepsy

    Pathophysiology
    Narcolepsy is a chronic disease of the central nervous system. Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. Other primary symptoms of narcolepsy include: loss of muscle tone (cataplexy), istorted perceptions (hypnagogic hallucinations), and inability to move or talk (sleep paralysis).

  • Narcolepsy

    Statistics
    Narcoleptics with long sleep time had a similar disease course and similar frequencies of cataplexy, sleep paralysis, hallucinations, multiple sleep onset in REM periods, short mean sleep latencies, and HLA DQB1*0602 positivity as narcoleptics with normal sleep time did. However, they had longer sleep time during 24 h, and higher sleep efficiency, lower Epworth Sleepiness Scale scores.

  • Narcolepsy

    Treatment
    1.Stimulants. Drugs that stimulate the central nervous system- modafinil or armodafinil 2.Selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs)- fluoxetine 3. Tricyclic antidepressants- protriptyline, imipramine 4.Sodium oxybate.

 

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