Nephrotic syndrome happens when tiny structures in the kidneys called glomeruli (gluh-MARE-you-lie) stop working properly and let too much protein enter the kidneys. In kids, this is usually due to a kidney condition called minimal change disease that affects the glomeruli. Nephrotic syndrome is more common in boys than girls, especially in kids younger than age 5. Fortunately, most cases (including those caused by minimal change disease) can be effectively treated with medicine. Most kids who get nephrotic syndrome as a result of minimal change disease eventually outgrow it by the teen years. A total of 71 children with an initial attack of idiopathic NS were allocated at random to the two groups.
The main functional units of the kidneys, where the blood filtering happens, are tiny organs called nephrons. Each kidney has about a million nephrons, and each nephron has one glomerulus (singular of glomeruli) a ball of tiny blood vessels, or capillaries. The glomerulus is the nephron's filter. This is where the process of removing waste products and fluids from the blood begins. Although the syndrome is caused by the loss of protein into your urine, eating a high-protein diet does not help and may actually make matters worse.