Non-ulcer dyspepsia (NUD) is a common problem wherein patients suffer from indigestion and other symptoms suggestive of an ulcer, but no abnormality is found on investigation. A maximum value of 34% in younger (25-35 years) males and 32% in older (35?65 years) females. 25% of the 40 year old Danish population had suffered epigastric pain during the year preceding the survey, and that 31% had experienced such pain at some point in their life. Treatment with medications has variable success.
Some patients obtain relief from antacids or acid-suppressing drugs, and some patients with symptoms suggestive of a problem with stomach emptying may be helped by medications which increase emptying. Antacids and sucralfate were found to be no better than placebo in a literature review. H2-RAs have been shown to have marked benefit in poor quality trials (30% relative risk reduction), but only a marginal benefit in good quality trials.