Rabies Virus can able to replicate in muscle and then binds to nicotinic acetylcholine receptors at neuromuscular junction. Virus travels within axons in peripheral nerves through retrograde fast axonal transport and Replication in motor neurons in spinal cord and local dorsal root ganglia and rapid ascent to brain. The main infected areas at brain neurons with neuronal dysfunction.
In Germany, mostly it is like complete pre-exposure series consists of three doses of vaccine injected into the deltoid muscle on days 0, 7, and 21 or 28. The vaccines used for pre-exposure and post-exposure vaccination are the same, but the immunization pattern is different. Even when pre-exposure vaccine has been received, urgent medical advice should be sought after any animal or bat bite.
Nine deaths from rabies were reported in Germany between 1981 and 2005. Two were caused by animal bites within Germany (one fox, one dog), and four were acquired abroad. In the remaining three cases, the source was a transplant from a donor who had died of rabies On 28 September 2008, the WHO for Animal Health declared Germany as free of rabies and the statistical rate of Germany is 76-80%.