Sclerosing mesenteritis is a rare condition of unknown cause that is characterized by chronic mesenteric inflammation . The process usually involves the mesentery of the small bowel, especially at its root, but can occasionally involve the mesocolon. Sclerosing mesenteritis is a rare benign condition that is found most often in elderly patients. Various terms are used throughout the literature to describe this condition, which may lead to confusion, especially since there is a paucity of data regarding this rare disease.
The significant symptomes for this disease are abdominal pain, nausea/vomiting, bloating, loss of appetite and diarrhea or constipation. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.
Sclerosing mesenteritis is itself non-neoplastic, but it is often associated with an underlying malignancy. Glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs.Several other medications such as azathioprine, colchicine, Cyclophosphamide and thalidomide. Sclerosing mesenteritis occurs when the tissue mesentery that holds the small intestines in place becomes inflamed and forms scar tissue.Sclerosing mesenteritis can cause abdominal pain, bloating and diarrhea.