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Ureteral Obstruction

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  • Ureteral Obstruction

     Pathophysiology

    Ureteral Obstruction is structural or functional hindrance of normal urine flow, sometimes leading to renal dysfunction (obstructive nephropathy). Ureteral obstruction can be classified as intraluminal or extraluminal. Intraluminal causes include kidney stones, blood clots and scarring; these conditions usually cause unilateral obstruction and Extraluminal causes include several conditions related to enlarged masses that place pressure on the ureter and create obstructions.

  • Ureteral Obstruction

     Disease statistics

    This is a relatively common condition in older men, due to prostatic enlargement: -Incidence of lower urinary tract symptoms (LUTs)/BPH averages 15 per 1,000 man-years. -In the age range 45-49, it is 3 per 1,000 man-years but increases to 38 per 1,000 man-years by age 75-79. -Acute urinary retention (AUR) is a relatively uncommon sequela, with a cumulative incidence of 2% over almost five years in men with symptomatic BPH.

  • Ureteral Obstruction

     Disease treatment

    Stents or drains placed in the ureter or in a part of the kidney called the renal pelvis may provide short-term relief of symptoms. Long-term relief from obstructive uropathy requires surgery. A Foley catheter, placed through the urethra into the bladder, may also be helpful.

  • Ureteral Obstruction

     Major research

    Although large amounts of animal and clinical research have been done, the pathophysiologic mechanisms accompanying UO are not fully elucidated, but it is now clear that obstructive nephropathy is not a simple result of mechanical impairment to urine flow but a complex syndrome resulting in alterations of both glomerular hemodynamics and tubular function..

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