alexa
Reach Us +44-1202-068036
Heavy Metal Toxicity and Therapeutics | OMICS International
ISSN: 2157-7609
Journal of Drug Metabolism & Toxicology

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Heavy Metal Toxicity and Therapeutics

Honglian Shi*

Pharmacology and Toxicology, University of Kansas, USA

*Corresponding Author:
Honglian Shi
Associate professor
Pharmacology and Toxicology
University of Kansas, USA
Tel: 785-864-6192
Fax: 785-864-5219
E-mail: [email protected]

Received date: September 26, 2013; Accepted date: October 05, 2013; Published date: October 08, 2013

Citation: Shi H (2013) Heavy Metal Toxicity and Therapeutics. J Drug Metab Toxicol 4:e120. doi: 10.4172/2157-7609.1000e120

Copyright: © 2013 Shi H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Drug Metabolism & Toxicology

It has long been known that heavy metal ions could be toxic and carcinogenic. Many metals such as arsenic and chromium induce cellular damages and carcinogenesis by increasing free radical generation and lowering cellular antioxidative defense capacity [1]. Targets of redox signaling induced by metals has been suggested to be potential therapeutic interventions in metal-induced toxicity and carcinogenesis. Aluminum is a known risk factor for neurodegeneration such as those in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. In the issue of volume 4 issue 4, Thirunavukkarasu et al. [2] reported aluminum and its salts extensively damaged nervous system and impaired learning and memory of rats. More interestingly, they demonstrated that Manasamitra vatakam (MMV), a berbo-minearal formulation, provided protection against aluminum-induced toxicity in the rats. Furthermore, MMV markedly increased synthesis and release of neurotransmitter 5-hydroxytryptamine and decreased the expression of apoptotic genes such as Bcl-2, Bcl-xL and and caspas-3.

Yet, it is not clear how MMV improves the level of 5-HT and apoptotic proteins in the rats exposed to aluminum. In addition, aluminum is known to cause oxidative stress. Does MMV effect on the antioxidative defense system? If so, how? Further investigation is needed to provide more insight to the mechanisms of MMV-mediated brain function improvement in neurodegeneration.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Article Usage

  • Total views: 12703
  • [From(publication date):
    December-2013 - Nov 20, 2018]
  • Breakdown by view type
  • HTML page views : 8867
  • PDF downloads : 3836
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7